Canpure CPEO-1080 Thermoelectric power plant ultrafiltration membrane Equivalent

Introduction

In the rapidly evolving biopharmaceutical industry, the demand for high-purity biologics—such as monoclonal antibodies (mAbs), vaccines, and recombinant proteins—has never been greater. As a leading Chinese manufacturer of ultrafiltration (UF) membranes, we specialize in cutting-edge filtration solutions designed to optimize downstream purification processes. Our self-developed UF membranes deliver unmatched performance in molecular separation, concentration, and diafiltration, ensuring compliance with FDA, EMA, and cGMP standards while offering cost efficiency and rapid production turnaround.

Why Our Ultrafiltration Membranes Stand Out

1. Superior Selectivity and High Yield

Our UF membranes are engineered for precise molecular weight cut-off (MWCO) control, enabling selective separation of target biomolecules (e.g., IgG, mRNA, AAV vectors) from impurities like host cell proteins (HCPs) and DNA fragments. Key advantages include:

High retention rates (>95%) for critical therapeutics, minimizing product loss.

Low fouling properties due to hydrophilic membrane materials, ensuring stable flux and extended membrane life.

Customizable pore sizes (1–300 kDa) to accommodate diverse applications, from virus concentration to buffer exchange.

2. Enhanced Process Efficiency with Continuous Flow Technology

Traditional batch ultrafiltration often faces challenges in scalability and buffer consumption. Our advanced tangential flow filtration (TFF) systems integrate single-pass ultrafiltration (SPTFF) technology, which:

Eliminates recirculation loops, reducing processing time by 20x compared to conventional methods.

Achieves >150 g/L antibody concentrations in a single pass, ideal for high-density biologics.

Reduces buffer usage by 15% while maintaining 99.9% diafiltration efficiency

3. Rigorous Compliance & Scalability

Our membranes are produced in a GMP-certified facility, ensuring:

Low extractables/leachables, critical for vaccine and gene therapy production.

Gamma-irradiated and pre-sterilized options for aseptic processing.

Seamless scale-up from lab to industrial volumes, supported by validated process parameters.

Key Applications in Biopharmaceutical Manufacturing

1. Monoclonal Antibody (mAb) Purification

Our 100–300 kDa UF membranes excel in IgG purification, effectively removing HCPs and aggregates while achieving >99% purity—superior to traditional chromatography methods.

2. Vaccine & Viral Vector Processing

For AAV, lentivirus, and mRNA vaccines, our membranes enable:

Virus concentration with >90% recovery rates.

Sterile filtration via low-adsorption membranes, preserving viral integrity.

3. Continuous Bioprocessing

Our SPTFF-compatible membranes support fully continuous downstream processing, reducing facility footprint and operational costs by 60%

Conclusion: A Trusted Partner for Global Biopharma

By combining precision separation, regulatory compliance, and cost-effective production, our ultrafiltration membranes empower biopharmaceutical companies to accelerate timelines and reduce costs. With short lead times and flexible customization, we are the ideal choice for R&D, pilot-scale, and commercial manufacturing.

Contact us today to discuss how our UF solutions can optimize your biologics purification pipeline!

Q&A

Q: What's the typical membrane surface area?

A: 50-100 m² per standard module.

Q: How to prevent biological growth?

A: Regular sanitization with chlorine or hydrogen peroxide.

Q: What's the maximum TDS removal?

A: Less than 10% - UF is not for desalination.