DupPont DOW SFP/SFD2660 Ultrafiltration Membrane for Electronic Grade Ultrapure Water Equivalent

Introduction

The biopharmaceutical industry demands stringent purification technologies to ensure the safety, efficacy, and consistency of injectable drugs, particularly in Traditional Chinese Medicine (TCM). Contaminants such as endotoxins, bacteria, and macromolecular impurities pose significant challenges, requiring advanced filtration methods that preserve active ingredients while achieving high purity.

As a leading Chinese manufacturer of ultrafiltration (UF) membranes, we specialize in high-performance, cost-effective UF solutions tailored for TCM injection purification, active ingredient recovery, and endotoxin removal. Our in-house membrane production ensures superior quality control, rapid delivery, and competitive pricing, making us the ideal partner for pharmaceutical companies seeking reliable, scalable filtration systems.

Critical Challenges in TCM Injection Production

TCM injections, such as Compound Danshen and Huangqin injections, face unique purification hurdles:

1. Endotoxin & Pyrogen Contamination – Bacterial endotoxins (lipopolysaccharides) must be reduced to <0.25 EU/mL to meet pharmacopeial standards (e.g., USP, ChP).

2. Macromolecular Impurities – Proteins, tannins, and polysaccharides can cause turbidity, precipitation, or adverse reactions.

3. Active Ingredient Loss – Traditional methods (e.g., alcohol precipitation) often degrade thermolabile compounds like flavonoids and glycosides.

4. Process Efficiency – Slow filtration and membrane fouling increase production costs and time.

Our UF membranes address these challenges through optimized pore structures, high flux rates, and chemical-resistant materials.

Key Advantages of Our Ultrafiltration Membranes

1. Precision Separation for Maximum API Retention

Molecular Weight Cut-Off (MWCO): 1,000–100,000 Da, selectively removing endotoxins (10–50 kDa) and bacteria while retaining small-molecule actives (e.g., danshensu, puerarin).

Case Study: For glycyrrhizinate injections, our 30 kDa UF membrane achieved >99% endotoxin clearance with <5% active loss, outperforming traditional methods.

2. Superior Fouling Resistance for Long-Term Stability

Hydrophilic PVDF/PES membranes minimize adhesion from TCM colloids and polyphenols.

Asymmetric pore design enhances shear-induced scouring, reducing cleaning frequency by 30%.

3. High-Efficiency Processing

Cross-flow filtration maintains steady flux rates (50–100 LMH), enabling continuous operation.

Automated systems reduce manual intervention, cutting labor costs by 20%

4. Cost-Effective Production & Fast Delivery

Vertical integration (from polymer synthesis to module assembly) ensures 40% lower costs than imported brands.

2–4 week lead time (vs. 8+ weeks for Western suppliers)

Applications in TCM Injection Production

1. Endotoxin & Microbial Removal

Problem: Endotoxins in saponin-rich injections (e.g., astragaloside IV) form micelles, complicating removal.

Solution: Our ultrasonic-assisted UF system disrupts micelles, achieving >99.5% endotoxin clearance without API loss.

2. Clarification of Herbal Extracts

Example: Salvia miltiorrhiza (Danshen) injections require removal of tannins and melanoidins.

Result: 50 kDa UF membranes improve transmittance to >95% while retaining danshensu and salvianolic acids.

3. Concentration of Active Fractions

Replaces thermal evaporation, preventing degradation of heat-sensitive compounds (e.g., ginsenosides).

Benefits: 50% energy savings, higher yield (90%+)

Technical Innovations

1. Ultrasonic-Enhanced UF – Combines 40 kHz ultrasound with dynamic filtration to prevent membrane fouling and boost endotoxin removal.

2. Customizable MWCO – Membranes tailored for specific TCM compounds (e.g., 10 kDa for epimedium flavonoids, 100 kDa for polysaccharides)

Conclusion

For TCM manufacturers prioritizing safety, efficiency, and cost, our ultrafiltration solutions deliver unmatched performance:

✅ GMP-compliant, endotoxin-free filtration

✅ Higher API recovery & lower operational costs

✅ Rapid deployment & dedicated support

Contact us today to optimize your TCM injection process with cutting-edge UF technology!

Q&A

Q: What's the main maintenance task for UF?

A: Regular backwashing and periodic chemical cleaning.

Q: Can UF remove chlorine?

A: No, chlorine molecules are too small to be filtered.

Q: Is UF water safe for drinking?

A: Yes, when properly maintained - removes pathogens effectively.